The follow-up to SLU-PP-332 from the same laboratory, redesigned so it works when swallowed. In mice it boosted endurance as well as the original, but like its predecessor it has never been studied in a human and is sold only as a research chemical.
SLU-PP-915 is a pan-agonist of the three estrogen-related receptors, ERRα, ERRβ, and ERRγ, with balanced potency across them rather than a preference for one. These orphan nuclear receptors control the genes for building new mitochondria, burning fat, and running the Krebs cycle and oxidative phosphorylation, which together let muscle sustain aerobic work. Turning them on mimics the gene response to a bout of aerobic exercise. In mice, both compounds strongly induced Ddit4, a gene switched on by acute aerobic exercise, at levels matching or exceeding treadmill running.
Swallowed as a pill (1/7)
SLU-PP-915 is swallowed, redesigned from SLU-PP-332 to survive the gut.
Unlike its predecessor, it survives passage through the gut, so an oral dose produces useful blood levels in mice. When combined with exercise training in mice it further raised Ddit4 and mitochondrial gene expression, which its makers read as synergy. Human liver microsomes convert it into seven metabolites, all from the first phase of metabolism, and three were confirmed by chemical synthesis. How quickly a person would absorb or clear it has never been measured.
SLU-PP-915 is sold online as an oral exercise mimetic. In mice it improved aerobic exercise performance, both distance and duration, about as much as SLU-PP-332 did when both were injected, and it kept that effect when given by mouth. In a mouse heart failure model it improved ejection fraction, reduced scarring, and increased survival. Its makers suggest future uses in obesity, type 2 diabetes, fatty liver disease, heart failure, and muscle wasting, none of which has been tested in people.
It is a chemically distinct molecule from SLU-PP-332 rather than a modified version, designed because the original lacked oral bioavailability. It has no sponsor seeking approval, no registered human trial, and no safety data in people. Online vendors sell it as a research chemical with no verification of identity, purity, or dose. Doping-control laboratories have already characterized how human liver enzymes break it down, in preparation for testing athletes.
The published record is smaller than SLU-PP-332's. One 2026 pharmacology paper describes the compound and its exercise-capacity effects in mice, one 2024 heart paper tested both compounds in a mouse heart failure model, and one 2026 analytical paper maps its metabolism in human liver preparations for doping control. All of the efficacy work comes from the laboratory that designed it. No human data of any kind exist.
Everything downstream of the mouse work is unknown: human pharmacokinetics, whether oral exposure in people resembles the mouse profile, chronic tolerability, and whether the metabolic benefits reported for SLU-PP-332 carry over to this analog. Independent replication has not been published. No first-in-human study is registered. Until one is, every dose taken outside a laboratory is an uncontrolled experiment.
No human side effects are known, because it has never been given to a person in a published study. The mouse experiments measured exercise capacity and heart function rather than toxicity, and ran for weeks rather than years. Switching on receptors that govern metabolism in heart, muscle, liver, and kidney has no human safety record. The oral route makes casual use easier without making it any better studied.
No regulator has approved this compound, and no company is seeking approval.
SLU-PP-915 is not approved anywhere and has no registered human trial. It is sold as a research chemical, outside the quality and labeling rules that apply to medicines. The World Anti-Doping Agency prohibits exercise mimetics and metabolic modulators, and the published metabolism work was done specifically so sports drug-testing programs can detect this compound. It should be treated as a prohibited substance in tested sport.