Prednisone is a man-made version of the steroid hormones the body makes naturally. It acts on tissues in nearly every organ system, reducing inflammation, swelling, and redness. It also changes how the immune system reacts to many different triggers. On top of that, it has wide effects on body chemistry, including how the body handles sugar, fat, salt, potassium, and calcium.
Taken for a long time, it signals the body's own steroid production to shut down, and this can last up to 12 months after stopping. Stopping suddenly can then leave the body short of steroids, with extreme tiredness, weakness, upset stomach, and salt craving. Because it weakens the immune system, it raises the risk of infections and can hide their signs. Its effects on calcium and bone building can thin the bones, and it can make the body hold salt and water and lose potassium.