Known brand names include No current brand name; marketed as generic ondansetron tablets and injection (the original brand was Zofran).
An antiemetic that blocks serotonin 5-HT3 receptors. It prevents nausea and vomiting from cancer chemotherapy, radiation therapy, and surgery. It comes as tablets and as an IV or IM injection.
Sources: [1]
The label does not describe a narrow therapeutic index or direct dosing by measured blood levels of the drug.
None on the current tablet or injection labels. QT prolongation and serotonin syndrome are labeled warnings instead.
No specific antidote; give supportive care. Very large IV doses have been given by mistake without major harm. Overdose has caused hypotension, brief blindness, and heart block, and serotonin syndrome in young children who swallowed tablets.
Sources: [1]
Doses come from the FDA label. Study tool, not for clinical decisions.
None for any degree of renal impairment, although clearance is lower when creatinine clearance is below 30 mL/min.