Known brand names include Advil, Motrin, Ibu, Genpril, Addaprin, Proprinal, and Wal-Profen.
An NSAID that eases pain, fever, and inflammation. Prescription tablets treat arthritis, mild to moderate pain, and menstrual cramps. It can cause stomach bleeding and raises the risk of heart attack and stroke, so the lowest dose for the shortest time is used.
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The label does not describe a narrow therapeutic index or direct dosing by measured blood levels of the drug.
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Cardiovascular thrombotic events: NSAIDs raise the risk of serious, possibly fatal heart attack and stroke, which may start early in treatment and grow with longer use; contraindicated around CABG surgery. Gastrointestinal risk: NSAIDs raise the risk of serious, possibly fatal GI bleeding, ulcers, and perforation, which can occur at any time without warning; older adults are at greater risk.
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No specific antidote. Overdose care is supportive; because the drug is acidic and excreted in urine, alkaline diuresis may help in theory.
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Doses come from the FDA label. Study tool, not for clinical decisions.
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Not recommended in advanced renal disease; if it must be used, monitor renal function closely. Impaired renal function, heart failure, liver dysfunction, diuretics, ACE inhibitors, and older age raise the risk of renal decompensation.
No labeled dose change. Borderline liver test rises are common, and rare severe hepatic reactions occur; stop if signs of liver disease develop.
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A nonselective NSAID. Its mode of action is not completely understood but is probably related to inhibiting prostaglandin synthesis, giving analgesic, antipyretic, and anti-inflammatory effects. In primary dysmenorrhea it lowers prostaglandin activity in menstrual fluid and reduces uterine pressure and contraction frequency. It inhibits platelet aggregation less than aspirin, and the effect is reversible and short.