Tricyclic antidepressants (TCAs)
Tricyclic antidepressants raise the levels of norepinephrine and serotonin in the brain by blocking their reuptake into nerve cells. Amitriptyline, nortriptyline, and imipramine are examples, and they are used mainly to treat depression. They also block acetylcholine and histamine, causing dry mouth, constipation, trouble urinating, blurred vision, drowsiness, and dizziness on standing. An overdose can cause deadly heart rhythm problems and seizures, and like other antidepressants they carry a warning about suicidal thoughts in children and young adults.