Albuterol acts mainly on beta-2 receptors, the main type found on the smooth muscle that wraps around the airways. Switching on these receptors raises a messenger inside the muscle cells called cyclic AMP, which lowers calcium levels in the cells and lets the muscle relax. The relaxation reaches every part of the airways, from the windpipe down to the smallest branches, whatever set off the tightening. Higher cyclic AMP is also linked to less release of chemical signals from mast cells in the airway.
In a study, people who responded began breathing better about 5 minutes after a dose on average, with the peak at about an hour and the effect usually lasting about 4 hours, sometimes up to 6. The heart also has some beta-2 receptors, so it can speed the pulse, change blood pressure, or alter the heart tracing in some people. It can briefly lower blood potassium and change blood sugar. Rarely, a puff tightens the airways instead of opening them, which can be life threatening and happens most often with the first use of a new canister.